Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28126128 | 0.84 | LMNA (0.60) | PDK1MAPTHCAR3ALDH1A1TSHR | |
| SCHEMBL2002281 | 0.84 | VCAM1 (0.57) | PDK1MAPTGAAALDH1A1CYP2D6 | |
| SCHEMBL11703265 | 0.82 | GPR35 (0.44) | PDK1GAAHCAR3ALDH1A1TSHR | |
| SCHEMBL31397894 | 0.81 | PDK1 (0.51) | PDK1MAPTGAAHCAR3ALDH1A1 | |
| SCHEMBL28644813 | 0.80 | KMT2A (0.58) | MAPTHCAR3ALDH1A1 | |
| SCHEMBL31397875 | 0.80 | PDK1 (0.47) | PDK1MAPTGAAHCAR3ALDH1A1 | |
| SCHEMBL27869888 | 0.80 | PDK1 (0.53) | PDK1MAPTGAAHCAR3ALDH1A1 | |
| SCHEMBL11701402 | 0.77 | PDK1 (0.43) | PDK1GAAHCAR3ALDH1A1TSHR | |
| SCHEMBL11631320 | 0.77 | TDP1 (0.53) | MAPTGAAALDH1A1TSHRLMNA | |
| SCHEMBL2552417 | 0.76 | MAPT (0.53) | MAPTGAAHCAR3CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0326307-B1 | Novel pyridazinone derivatives and pharmaceutical preparations containing them | KYOWA HAKKO KOGYO KK (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5063227-A | QUINAZOLINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES HAVING CARDIOTONIC ACTIVITY | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |
| EP-0326307-A2 | Novel pyridazinone derivatives and pharmaceutical preparations containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |