Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RASGRP1 | O95267 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7325102 | 0.82 | HTR3A (0.58) | NR4A2LMNAPOLBHTR3EHTR3B | |
| Maleic Acid SCHEMBL7325100 | 0.82 | HTR3A (0.58) | NR4A2LMNAPOLBHTR3EHTR3B | |
| Maleic Acid SCHEMBL7276372 | 0.81 | BRD4 (0.46) | NR4A2LMNAPOLBHTR3EHTR3B | |
| Fumaric Acid SCHEMBL7276376 | 0.81 | BRD4 (0.46) | NR4A2LMNAPOLBHTR3EHTR3B | |
| SCHEMBL11233424 | 0.73 | POLB (0.62) | NR4A2LMNAPOLBNPSR1MITF | |
| SCHEMBL6379635 | 0.71 | NR4A2 (0.69) | NR4A2LMNAPOLBNPSR1MITF | |
| SCHEMBL27753754 | 0.71 | TDP1 (0.53) | LMNAPOLBNPSR1ALDH1A1MAPT | |
| SCHEMBL28991624 | 0.69 | NR4A2 (0.66) | NR4A2LMNAPOLBNPSR1MITF | |
| Fumaric Acid SCHEMBL7269207 | 0.69 | EGFR (0.42) | POLBNPSR1ALDH1A1MAPTHTT | |
| Fumaric Acid SCHEMBL7317811 | 0.69 | HTR3E (0.57) | NR4A2LMNAPOLBHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026722-A | Antagonists of 5-hydroxytryptamine | GLAXO GROUP LIMITED (GB) | 1991-06-25 | — | — | US | disclosed |
| EP-0347229-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |