Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | RAPGEF3 | O95398 | 6/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.32 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.31 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.30 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008766 | 0.89 | RAPGEF3 (0.40) | RAPGEF3RAPGEF4GAA | |
| SCHEMBL166050 | 0.83 | HDAC4 (0.41) | — | |
| SCHEMBL1008191 | 0.80 | MDM2 (0.40) | RAPGEF3 | |
| SCHEMBL20767316 | 0.79 | SLC6A3 (0.41) | HTRA1AKR1C3AKR1C2 | |
| SCHEMBL9956248 | 0.79 | PDK1 (0.30) | — | |
| SCHEMBL5073551 | 0.78 | ALDH1A1 (0.32) | RAPGEF3 | |
| SCHEMBL6049547 | 0.77 | BRD4 (0.36) | GRNSORT1RAPGEF3RAPGEF4TPMT | |
| SCHEMBL9271806 | 0.76 | GRN (0.36) | GRNSORT1RAPGEF3RAPGEF4 | |
| SCHEMBL1005803 | 0.75 | PPARD (0.33) | AKR1C3AKR1C2 | |
| SCHEMBL6097343 | 0.75 | TSHR (0.44) | AKR1C3AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | disclosed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |