Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF3 | O95398 | 10/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.40 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.33 |
| ▸ | MICA | Q29983 | 1/20 | 0.33 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271607 | 0.89 | GRN (0.35) | RAPGEF3RAPGEF4GAA | |
| Water SCHEMBL943020 | 0.79 | RXRA (0.40) | RAPGEF3RAPGEF4GAAHDAC3HDAC1 | |
| SCHEMBL3728532 | 0.79 | RXRA (0.40) | RAPGEF3RAPGEF4GAAHDAC3HDAC1 | |
| SCHEMBL10850710 | 0.79 | RAPGEF3 (0.38) | RAPGEF3RAPGEF4SLC13A3DDR1KLRK1 | |
| SCHEMBL10773057 | 0.77 | CNR2 (0.41) | RAPGEF3RAPGEF4TACR1 | |
| SCHEMBL166050 | 0.76 | HDAC4 (0.41) | L3MBTL1ALDH1A1 | |
| SCHEMBL7097950 | 0.74 | GAA (0.39) | RAPGEF3RAPGEF4SLC13A3GAADDR1 | |
| SCHEMBL1008191 | 0.73 | MDM2 (0.40) | RAPGEF3L3MBTL1 | |
| SCHEMBL20767316 | 0.73 | SLC6A3 (0.41) | ALDH1A1PKM | |
| SCHEMBL9956248 | 0.72 | PDK1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374791-A1 | Insecticidal 4-phenyl-1H pyrazoles | Bayer CropScience Aktiengesellschaft (DE) | 2011-10-12 | — | — | EP | disclosed |
| US-20110190365-A1 | Insecticidal 4-phenyl-1H-pyrazoles | BAYER CROP SCIENCE AG (DE) | 2011-08-04 | — | — | US | disclosed |
| EP-2321262-A1 | INSECTICIDAL 4-PHENYL-1H-PYRAZOLES | Bayer CropScience AG (DE) | 2011-05-18 | — | — | EP | disclosed |
| EP-2125789-B1 | PYRIMIDINYL PYRAZOLES AS INSECTICIDES AND PARASITICIDE ACTIVE AGENTS | BAYER CROPSCIENCE AG (DE) | 2011-03-16 | — | — | EP | disclosed |
| EP-2275422-A1 | Pyrimidinylpyrazoles as insecticide and parasiticide agents | Bayer CropScience AG (DE) | 2011-01-19 | — | — | EP | disclosed |
| US-20100144672-A1 | PYRIMIDINYL PYRAZOLES AS INSECTICIDES AND PARASITICIDE ACTIVE AGENTS | BAYER CROPSCIENCE AG (DE) | 2010-06-10 | — | — | US | disclosed |
| WO-2010017902-A1 | INSECTICIDAL 4-PHENYL-1H-PYRAZOLES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-02-18 | — | — | WO | disclosed |
| EP-2125789-A1 | PYRIMIDINYL PYRAZOLES AS INSECTICIDES AND PARASITICIDE ACTIVE AGENTS | Bayer CropScience AG (DE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077483-A1 | PYRIMIDINYL PYRAZOLES AS INSECTICIDES AND PARASITICIDE ACTIVE AGENTS | BAYER CROPSCIENCE AG (DE) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190365-A1 | Insecticidal 4-phenyl-1H-pyrazoles | CYP4X1, CYP4B1, CYP3A4 | RAPGEF3 447/4885RAPGEF4 495/4885SLC13A3 3016/4885 |
| US-20100144672-A1 | PYRIMIDINYL PYRAZOLES AS INSECTICIDES AND PARASITICIDE ACTIVE AGENTS | PIR, ITPA, DDT | RAPGEF3 759/4885RAPGEF4 1141/4885SLC13A3 3499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.