Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278990 | 0.82 | PDE3B (0.47) | PDE3BPDE3ANPSR1CYP1A2CYP2C9 | |
| SCHEMBL28649440 | 0.81 | PDE3B (0.45) | PDE3BPDE3ANPC1RAB9APIK3R1 | |
| SCHEMBL11241215 | 0.79 | KIF11 (0.37) | PDE3BPDE3ANPSR1NPC1RAB9A | |
| SCHEMBL7278230 | 0.79 | PIK3R1 (0.36) | NPC1RAB9AHTTSMN1; SMN2GCGR | |
| SCHEMBL7280088 | 0.77 | DYRK1A (0.43) | PDE3BPDE3ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7282577 | 0.76 | CYP2C19 (0.75) | PDE3BPDE3ANPSR1CYP1A2CYP2C9 | |
| SCHEMBL11248447 | 0.75 | SMN1; SMN2 (0.40) | PDE3BPDE3ANPSR1NPC1RAB9A | |
| SCHEMBL11241318 | 0.73 | RAB9A (0.45) | PDE3BPDE3ANPSR1CYP1A2CYP2C9 | |
| SCHEMBL11163990 | 0.73 | CASP1 (0.55) | PDE3BPDE3AMAPT | |
| SCHEMBL11382839 | 0.71 | CYP46A1 (0.58) | PDE3BPDE3ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4463008-A | 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof | STERLING DRUG INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0109027-A1 | Pyridine derivatives, process for their preparation and composition containing them | STERLING DRUG INC. (US) | 1984-05-23 | — | — | EP | disclosed |
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |