Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | GCGR | P47871 | 5/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254135 | 0.84 | KIF11 (0.39) | KIF11S1PR1S1PR3TRPV1GCGR | |
| SCHEMBL28506866 | 0.83 | KIF11 (0.38) | KIF11S1PR1S1PR3GCGRNPC1 | |
| SCHEMBL7272903 | 0.79 | PDE3B (0.44) | GCGRMAPK14NPC1RAB9AHTT | |
| SCHEMBL11231069 | 0.78 | CYP2C19 (0.50) | KIF11MAPK14LMNAHPGDTSHR | |
| SCHEMBL11235418 | 0.76 | RAB9A (0.43) | TRPV1NPC1RAB9AMAPTLMNA | |
| SCHEMBL11158174 | 0.76 | CASP1 (0.51) | MAPT | |
| SCHEMBL7278230 | 0.75 | PIK3R1 (0.36) | GCGRMAPK14NPC1RAB9AHTT | |
| SCHEMBL11173175 | 0.73 | KIF11 (0.41) | KIF11S1PR1S1PR3TRPV1GCGR | |
| SCHEMBL11248447 | 0.72 | SMN1; SMN2 (0.40) | S1PR1GCGRMAPK14NPC1RAB9A | |
| SCHEMBL21339368 | 0.71 | PTGS2 (0.49) | KIF11GCGRMAPK14NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |