Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | ACHE | P22303 | 4/20 | 0.54 |
| ▸ | BCHE | P06276 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268018 | 0.82 | KDM4E (0.65) | L3MBTL1MAPK1ALDH1A1ACHEBCHE | |
| SCHEMBL11115732 | 0.81 | ACKR3 (0.45) | L3MBTL1MAPK1ALDH1A1HTTKDM4E | |
| SCHEMBL11639395 | 0.81 | ALDH1A1 (0.61) | L3MBTL1ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL7721920 | 0.78 | TP53 (0.57) | L3MBTL1MAPK1ALDH1A1HTTLPAR1 | |
| SCHEMBL7318334 | 0.78 | POLB (0.52) | L3MBTL1MAPK1ALDH1A1ACHEBCHE | |
| SCHEMBL9545203 | 0.77 | HSP90AA1 (0.61) | L3MBTL1MAPK1ALDH1A1HTTMEN1 | |
| SCHEMBL15720901 | 0.76 | KDM4E (0.73) | L3MBTL1MAPK1ALDH1A1ACHEBCHE | |
| SCHEMBL9750679 | 0.76 | SCN1A (0.49) | L3MBTL1MAPK1ALDH1A1HTTKDM4E | |
| SCHEMBL9750780 | 0.75 | ACHE (0.55) | L3MBTL1MAPK1ALDH1A1ACHEBCHE | |
| Hydrochloric Acid SCHEMBL9750696 | 0.74 | SCN1A (0.48) | L3MBTL1MAPK1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293925-B1 | COMPOUND ACTIVE IN CARDIOVASCULAR THERAPY | SIMES, SOCIETA ITALIANA MEDICINALI E SINTETICI, S.P.A. (IT) | 1991-10-16 | — | — | EP | disclosed |
| US-4988735-A | Ethylene diamine active cardiovascular therapy | SIMES (IT) | 1991-01-29 | — | — | US | disclosed |
| EP-0293925-A2 | Compound active in cardiovascular therapy | SIMES, SOCIETA ITALIANA MEDICINALI E SINTETICI, S.P.A. (IT) | 1988-12-07 | — | — | EP | disclosed |