Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.46 |
| ▸ | ANPEP | P15144 | 4/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.43 |
| ▸ | IL1RN | P18510 | 2/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286158 | 0.86 | MMP2 (0.48) | RENANPEPERAP2ERAP1MMP2 | |
| SCHEMBL7277213 | 0.85 | REN (0.44) | RENANPEPERAP2ERAP1MMP2 | |
| SCHEMBL7277678 | 0.84 | MME (0.48) | MMP2MMP9MMP8 | |
| SCHEMBL10718705 | 0.84 | REN (0.46) | RENANPEPERAP1MMP2MMP9 | |
| SCHEMBL7284698 | 0.83 | ACE2 (0.51) | RENANPEPERAP1MMP2MMP9 | |
| SCHEMBL7283367 | 0.83 | ACE2 (0.51) | RENANPEPERAP1MMP2MMP9 | |
| SCHEMBL7308401 | 0.82 | ECE1 (0.53) | RENANPEPERAP1MMP2MMP9 | |
| SCHEMBL11012642 | 0.82 | ANPEP (0.41) | RENANPEPERAP2ERAP1IL1RN | |
| SCHEMBL10720722 | 0.82 | ANPEP (0.41) | RENANPEPERAP2ERAP1IL1RN | |
| SCHEMBL7274934 | 0.82 | REN (0.45) | RENANPEPERAP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210545-A2 | Phosphorous containing enzyme inhibitors | MERCK & CO. INC. (US) | 1987-02-04 | — | — | EP | disclosed |
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |