Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275707 | 0.94 | OPRM1 (0.35) | — | |
| SCHEMBL7283239 | 0.91 | DRD2 (0.39) | DRD2DRD4PTGER4CHRNB2CHRNB4 | |
| SCHEMBL7273363 | 0.89 | MMP12 (0.37) | PTGER4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7274705 | 0.87 | MCHR1 (0.37) | DRD4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7278829 | 0.86 | KAT6A (0.35) | DRD4 | |
| SCHEMBL7273436 | 0.85 | ALDH1A1 (0.36) | DRD2DRD4PTGER4FAAH | |
| SCHEMBL7275596 | 0.83 | DRD2 (0.41) | DRD2DRD4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7283079 | 0.82 | MDM2 (0.34) | — | |
| SCHEMBL7284963 | 0.82 | MDM2 (0.34) | — | |
| SCHEMBL7284708 | 0.82 | OPRM1 (0.35) | DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |