Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.52 |
| ▸ | CTSD | P07339 | 4/20 | 0.47 |
| ▸ | REN | P00797 | 4/20 | 0.47 |
| ▸ | CTSK | P43235 | 5/20 | 0.45 |
| ▸ | CTSB | P07858 | 4/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CTSE | P14091 | 1/20 | 0.43 |
| ▸ | PGC | P20142 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9011705 | 0.89 | REN (0.50) | CTSLRENCTSKCTSBCTSS | |
| SCHEMBL7434284 | 0.85 | CTSK (0.51) | CTSLRENCTSKCTSBCTSS | |
| SCHEMBL7329100 | 0.85 | CTSK (0.51) | CTSLRENCTSKCTSBCTSS | |
| SCHEMBL7279621 | 0.85 | CTSD (0.52) | CTSLCTSDRENCTSKCTSB | |
| SCHEMBL7429221 | 0.84 | CTSK (0.52) | CTSLRENCTSKCTSBCTSS | |
| SCHEMBL7269917 | 0.83 | CTSL (0.57) | CTSLCTSKCTSBCTSSELANE | |
| SCHEMBL8120691 | 0.83 | CTSD (0.61) | CTSLCTSDRENCTSKCTSB | |
| SCHEMBL7278761 | 0.80 | REN (0.50) | CTSLRENCTSKCTSBCTSS | |
| SCHEMBL25285984 | 0.80 | CTSL (0.64) | CTSLCTSKCTSBCTSSELANE | |
| SCHEMBL25285983 | 0.80 | CTSL (0.64) | CTSLCTSKCTSBCTSSELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402646-B1 | Retroviral protease inhibiting compounds | ABBOTT LAB (US) | 1998-07-22 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |