Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283757 | 0.85 | ACHE (0.56) | ACHEEPHX1MEN1KMT2ABACE1 | |
| SCHEMBL7809522 | 0.84 | ACHE (0.64) | ACHEEPHX1MEN1KMT2ABACE1 | |
| SCHEMBL4678438 | 0.81 | ACHE (0.63) | ACHEEPHX1MEN1KMT2ABACE1 | |
| SCHEMBL13803669 | 0.81 | ACHE (0.59) | ACHEEPHX1MEN1KMT2AALDH1A1 | |
| SCHEMBL2781381 | 0.80 | MEN1 (0.68) | ACHEEPHX1MEN1KMT2AL3MBTL3 | |
| SCHEMBL4677007 | 0.79 | ACHE (0.59) | ACHEEPHX1MEN1KMT2AALDH1A1 | |
| SCHEMBL7288369 | 0.78 | BCHE (0.64) | ACHE | |
| SCHEMBL27748883 | 0.78 | ACHE (0.68) | ACHEEPHX1MEN1KMT2ABACE1 | |
| SCHEMBL27297520 | 0.78 | KCNA5 (0.57) | ACHEEPHX1MEN1KMT2AALDH1A1 | |
| SCHEMBL27733598 | 0.77 | LMNA (0.57) | ACHEEPHX1MEN1KMT2ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0063365-B2 | 1,4-Dihydropyridine derivative and pharmaceutical composition containing same | KYOWA HAKKO KOGYO KK (JP) | 1994-06-15 | — | — | EP | disclosed |
| EP-0063365-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-09-04 | — | — | EP | disclosed |
| US-4448964-A | HYPOTENSIVE AGENTS; VASODILATORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1984-05-15 | — | — | US | disclosed |
| EP-0063365-A1 | 1,4-Dihydropyridine derivative and pharmaceutical composition containing same | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1982-10-27 | — | — | EP | disclosed |