Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.52 |
| ▸ | NQO2 | P16083 | 6/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272139 | 0.86 | LMNA (0.58) | MTNR1AMTNR1BNQO2CYP19A1ACHE | |
| SCHEMBL6401395 | 0.86 | CYP19A1 (0.49) | MTNR1AMTNR1BNQO2CYP19A1ACHE | |
| SCHEMBL6401397 | 0.86 | CYP19A1 (0.49) | MTNR1AMTNR1BNQO2CYP19A1ACHE | |
| SCHEMBL6087432 | 0.76 | CYP24A1 (0.50) | MTNR1AMTNR1BNQO2CYP19A1 | |
| SCHEMBL345475 | 0.76 | ACHE (0.51) | MTNR1AMTNR1BNQO2CYP19A1ACHE | |
| SCHEMBL7302984 | 0.75 | CYP19A1 (0.60) | MTNR1AMTNR1BNQO2CYP19A1ACHE | |
| SCHEMBL7210331 | 0.75 | CA1 (0.70) | MTNR1AMTNR1BNQO2ACHE | |
| SCHEMBL7337809 | 0.75 | CA1 (0.70) | MTNR1AMTNR1BNQO2ACHE | |
| SCHEMBL8435265 | 0.74 | ALDH1A1 (0.56) | MTNR1AMTNR1BNQO2CYP19A1ACHE | |
| SCHEMBL1877585 | 0.74 | ACHE (0.52) | MTNR1AMTNR1BNQO2CYP19A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4420480-A | PARKINSONISM, DEPRESSION, HYPOTENSIVES | MERCK & CO., INC. (US) | 1983-12-13 | — | — | US | disclosed |
| EP-0080115-A2 | Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them | MERCK & CO. INC. (US) | 1983-06-01 | — | — | EP | disclosed |