Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362812 | 0.98 | METAP2 (0.42) | HSD11B1METAP2HPGDMEN1KMT2A | |
| SCHEMBL30877175 | 0.91 | FAAH (0.42) | METAP2HPGDMAPTALDH1A1TDP1 | |
| SCHEMBL7641554 | 0.90 | CYP1A2 (0.46) | METAP2NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL25062701 | 0.82 | METAP2 (0.41) | HSD11B1METAP2HPGDMEN1KMT2A | |
| SCHEMBL1172293 | 0.81 | MEN1 (0.54) | HSD11B1HPGDMEN1KMT2AMAPT | |
| SCHEMBL31323929 | 0.81 | MEN1 (0.54) | HSD11B1HPGDMEN1KMT2AMAPT | |
| SCHEMBL9744436 | 0.81 | MEN1 (0.54) | HSD11B1HPGDMEN1KMT2AMAPT | |
| SCHEMBL4737887 | 0.81 | ALDH1A1 (0.41) | METAP2HPGDKMT2AMAPTATM | |
| SCHEMBL18311726 | 0.81 | MEN1 (0.54) | HSD11B1HPGDMEN1KMT2AMAPT | |
| SCHEMBL16761652 | 0.80 | NAAA (0.36) | METAP2MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103298468-A | Ring-fused heterocyclic derivative | KYOWA HAKKO KIRIN CO LTD | 2013-09-11 | — | — | CN | disclosed |
| US-4897379-A | N-[N.sup.α -(1(S)-carboxy-3-cyclohexylpropyl)-L-lysyl]-N-cyclopentylglycine as antihypertensives | ASAHI BREWERIES LTD. (JP) | 1990-01-30 | — | — | US | disclosed |
| EP-0284510-A2 | N-[N alpha-(1(S)-carboxy-3-cyclohexyl-propyl)-1-lysyl] N-cyclopentylglycine as antihypertensives | Asahi Breweries, Ltd. (JP) | 1988-09-28 | — | — | EP | disclosed |
| US-4591458-A | ENZYME INHIBITORS; HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-05-27 | — | — | US | disclosed |
| US-4564612-A | ANGIOTENSION CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS, BENZOTHIAZEPINES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-01-14 | — | — | US | disclosed |
| US-4548932-A | ANGIOTENSIN INHIBITOR, HYPOTENSIVE AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-10-22 | — | — | US | disclosed |
| EP-0135349-A1 | Condensed seven-membered ring compounds and their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-03-27 | — | — | EP | disclosed |
| EP-0125056-A2 | Condensed, seven-membered ring compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1984-11-14 | — | — | EP | disclosed |