Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30877175 | 0.85 | FAAH (0.42) | FAAHMETAP2MAPTALDH1A1GAA | |
| SCHEMBL19276848 | 0.84 | ALDH1A1 (0.42) | NAAAASAH1MAPTALDH1A1GAA | |
| SCHEMBL7362812 | 0.82 | METAP2 (0.42) | FAAHMETAP2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7280876 | 0.80 | HSD11B1 (0.44) | FAAHMETAP2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL15566435 | 0.75 | GAA (0.37) | MAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL19806324 | 0.73 | TSHR (0.41) | NAAAASAH1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2778453 | 0.73 | TRPA1 (0.41) | NAAAASAH1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL17933288 | 0.72 | PSEN1 (0.39) | NAAAASAH1MAPT | |
| SCHEMBL27939502 | 0.72 | JAK2 (0.31) | NAAAASAH1MAPTALDH1A1JAK2 | |
| SCHEMBL12201811 | 0.71 | CYP3A4 (0.35) | NAAAASAH1METAP2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2881394-B1 | CONDENSED RING HETEROCYCLIC COMPOUND | KYOWA HAKKO KIRIN CO LTD (JP) | 2018-03-21 | — | — | EP | disclosed |
| US-9540366-B2 | Ring-fused heterocyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2017-01-10 | — | — | US | disclosed |
| US-20150284384-A1 | RING-FUSED HETEROCYCLIC COMPOUND | KYOWA KIRIN CO., LTD. (JP) | 2015-10-08 | — | — | US | disclosed |
| EP-2881394-A1 | CONDENSED RING HETEROCYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2015-06-10 | — | — | EP | disclosed |
| CN-104619707-A | Condensed ring heterocyclic compound | KYOWA HAKKO KIRIN CO LTD | 2015-05-13 | — | — | CN | disclosed |
| CN-103298468-A | Ring-fused heterocyclic derivative | KYOWA HAKKO KIRIN CO LTD | 2013-09-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284384-A1 | RING-FUSED HETEROCYCLIC COMPOUND | TRPV1, TRPV2, TRPV3 | NAAA 1878/4885ASAH1 3017/4885FAAH 1645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.