Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11836816 | 0.79 | PTGS2 (0.40) | APP | |
| SCHEMBL11778841 | 0.79 | CXCR1 (0.39) | — | |
| SCHEMBL7282009 | 0.77 | MMP9 (0.33) | — | |
| SCHEMBL7282243 | 0.75 | ALOX5 (0.48) | — | |
| SCHEMBL11078116 | 0.74 | ALDH1A1 (0.42) | — | |
| SCHEMBL7289374 | 0.73 | LMNA (0.47) | EPHX1 | |
| SCHEMBL5441902 | 0.72 | BRD4 (0.45) | BRD4 | |
| SCHEMBL7431895 | 0.72 | ESR1 (0.41) | — | |
| SCHEMBL22504104 | 0.72 | ACHE (0.40) | EPHX1 | |
| SCHEMBL1395758 | 0.71 | HDAC3 (0.44) | EPHX1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |