Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283546 | 1.00 | HTR1A (0.40) | HTR1ADRD2PRCP | |
| SCHEMBL9824237 | 0.89 | HTR1A (0.40) | HTR1ADRD2PRCP | |
| SCHEMBL7986246 | 0.80 | PRCP (0.44) | HTR1ADRD2PRCP | |
| SCHEMBL26616960 | 0.80 | LMNA (0.36) | DRD2 | |
| SCHEMBL26622428 | 0.80 | LMNA (0.36) | DRD2 | |
| SCHEMBL28236427 | 0.79 | PRCP (0.43) | HTR1ADRD2PRCP | |
| SCHEMBL4959151 | 0.77 | DRD2 (0.49) | HTR1ADRD2 | |
| SCHEMBL10840848 | 0.77 | DRD2 (0.49) | HTR1ADRD2 | |
| SCHEMBL7272572 | 0.77 | DRD2 (0.49) | HTR1ADRD2 | |
| SCHEMBL7272577 | 0.77 | DRD2 (0.49) | HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139393-B1 | PYRIMIDO(4,5-G)QUINOLINES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| EP-0127708-B1 | TRANS-DL-1-ALKYL-6-ALKOXYOCTAHYDROQUINOLINES | ELI LILLY AND COMPANY (US) | 1987-09-09 | — | — | EP | disclosed |
| US-4626591-A | Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4540787-A | Method of preparing trans-D1-1-alkyl-6-oxodecahydroquinolines | ELI LILLY AND COMPANY (US) | 1985-09-10 | — | — | US | disclosed |
| US-4521421-A | USING 2-AMINO-OCTAHYDROPYRIMIDO(4,5-G)QUINOLINE COMPOUND | ELI LILLY AND COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0142920-A2 | 6-Oxodecahydroquinolines and process for their preparation | ELI LILLY AND COMPANY (US) | 1985-05-29 | — | — | EP | disclosed |
| EP-0139393-A2 | Pyrimido(4,5-g)quinolines, process for their preparation, and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1985-05-02 | — | — | EP | disclosed |
| EP-0127708-A1 | Trans-dl-1-alkyl-6-alkoxyoctahydroquinolines | ELI LILLY AND COMPANY (US) | 1984-12-12 | — | — | EP | disclosed |
| US-4367231-A | PARKINSON*S SYNDROME | ELI LILLY AND COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| US-4230861-A | DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |
| EP-0013787-A1 | Octahydro pyrazolo (3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4198415-A | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines | ELI LILLY AND COMPANY (US) | 1980-04-15 | — | — | US | disclosed |