Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.41 |
| ▸ | CPA1 | P15085 | 3/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285383 | 1.00 | MME (0.46) | MMEECE1CTSLCTSSSIRT2 | |
| SCHEMBL7278943 | 0.85 | MME (0.49) | MMEECE1CTSLCTSSSIRT2 | |
| SCHEMBL7142898 | 0.82 | SMPD2 (0.43) | CASP1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL7448373 | 0.82 | SMPD2 (0.43) | CASP1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL7138305 | 0.80 | CASP1 (0.41) | CASP1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL8755316 | 0.78 | EPHX1 (0.38) | SIRT2SIRT1ALDH1A1HPGDMEN1 | |
| SCHEMBL9826099 | 0.77 | ALDH1A1 (0.44) | CASP1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7279460 | 0.76 | CTSL (0.46) | MMEECE1CTSLCTSSSIRT2 | |
| SCHEMBL5050403 | 0.76 | CPB1 (0.54) | MMEECE1SIRT2SIRT1ACE | |
| SCHEMBL7278952 | 0.76 | CTSL (0.49) | MMEECE1CTSLCTSSSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4851387-A | RENIN INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0264106-A2 | 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use | Banyu Pharmaceutical Co., Ltd. (JP) | 1988-04-20 | — | — | EP | disclosed |