Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9490716 | 0.84 | ALOX5 (0.63) | ALOX5MEN1KMT2AELANEPTPN1 | |
| SCHEMBL4841858 | 0.84 | ALDH1A1 (0.54) | ALOX5MEN1KMT2AMAOBPTPN1 | |
| SCHEMBL5883601 | 0.82 | L3MBTL1 (0.52) | ALOX5MEN1KMT2AMAOBSMN1; SMN2 | |
| SCHEMBL5111326 | 0.81 | BCHE (0.49) | ALOX5MEN1KMT2AMAOBPTGS1 | |
| SCHEMBL9650321 | 0.81 | LTB4R (0.57) | ALOX5MEN1KMT2AMAOBNR4A2 | |
| SCHEMBL8000403 | 0.80 | MAOB (0.57) | ALOX5MEN1KMT2AMAOBPTPN1 | |
| SCHEMBL4363943 | 0.80 | MAOB (0.57) | ALOX5MEN1KMT2AMAOBPTPN1 | |
| Phenol SCHEMBL17389166 | 0.80 | ALOX5 (0.55) | ALOX5MEN1KMT2AELANEPTPN1 | |
| SCHEMBL4847906 | 0.79 | PTPN1 (0.63) | ALOX5MAOBPTPN1PTGS1NR4A2 | |
| SCHEMBL4840332 | 0.78 | FFAR1 (0.55) | MAOBPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6359138-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2002-03-19 | — | — | US | disclosed |
| EP-0846683-B1 | 4-Hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-09-19 | — | — | EP | disclosed |
| EP-0846683-A1 | 4-Hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-06-10 | — | — | EP | disclosed |