Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21009569 | 0.90 | ADRA1B (0.58) | DRD2DRD3ADRA1BADRA1AADRA1D | |
| SCHEMBL11808012 | 0.87 | ALDH1A1 (0.67) | DRD2DRD3ADRA1BADRA1AADRA1D | |
| SCHEMBL14067200 | 0.86 | HTR7 (0.59) | ADRA1BADRA1AADRA1DHTR7ADRB1 | |
| SCHEMBL18182310 | 0.84 | DRD2 (0.64) | DRD2DRD3ADRA1BADRA1AADRA1D | |
| SCHEMBL10730439 | 0.83 | ALDH1A1 (0.63) | DRD2DRD3ADRA1BADRA1AADRA1D | |
| SCHEMBL9645654 | 0.83 | ADRA1B (0.57) | DRD2DRD3ADRA1BADRA1AADRA1D | |
| SCHEMBL10415957 | 0.83 | ADRA1B (0.57) | DRD2DRD3ADRA1BADRA1AADRA1D | |
| SCHEMBL3436474 | 0.81 | AKR1C3 (0.61) | DRD2DRD3ADRA1BADRA1AADRA1D | |
| SCHEMBL4291189 | 0.81 | ADRB1 (0.72) | ADRA1BADRA1AADRA1DHTR7ALDH1A1 | |
| SCHEMBL2114057 | 0.81 | ALDH1A1 (0.58) | DRD2DRD3ADRA1BADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014079504-A1 | POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF | BIOFORDRUG S.R.L. (IT) | 2014-05-30 | — | — | WO | disclosed |
| EP-0094159-B1 | DIHYDROPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-03-14 | — | — | EP | disclosed |
| US-4892875-A | HYPOTENSIVE, RENAL VASODILATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| US-4603135-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-29 | — | — | US | disclosed |
| EP-0138505-A2 | Dihydropyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-04-24 | — | — | EP | disclosed |
| EP-0094159-A1 | Dihydropyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-11-16 | — | — | EP | disclosed |