Phorbol

Phorbol

SCHEMBL72895

CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CCCCCCCCCCCCCCOC(C)=O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 6/20 0.62
PRKCG P05129 6/20 0.62
PRKD3 O94806 5/20 0.62
PRKCB P05771 5/20 0.62
PRKCH P24723 5/20 0.62
PRKCI P41743 5/20 0.62
PRKCE Q02156 5/20 0.62
PRKCQ Q04759 5/20 0.62
PRKCZ Q05513 5/20 0.62
PRKCD Q05655 5/20 0.62
PRKD1 Q15139 5/20 0.62
USP2 O75604 2/20 0.62
TP53 P04637 2/20 0.62
KDM4E B2RXH2 1/20 0.62
ALDH1A1 P00352 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2C9 P11712 1/20 0.62
TSHR P16473 1/20 0.62
NFKB1 P19838 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phorbol SCHEMBL27572795 1.00 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL11123948 0.91 PRKCA (0.61) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL7566989 0.89 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL29134149 0.89 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL20582541 0.89 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL417521 0.89 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL1893791 0.89 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL10620832 0.89 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27616694 0.89 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL21462215 0.89 PRKCA (0.66) PRKCAPRKCGPRKD3PRKCBPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 470 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090221005-A1 METHOD FOR DETECTING ANTIGEN SPECIFIC OR MITOGEN-ACTIVATED T CELLS ST VINCENT'S HOSPITAL SYDNEY LIMITED (AU) 2009-09-03 US claimed
EP-1996936-A4 A METHOD FOR DETECTING ANTIGEN-SPECIFIC OR MITOGEN-ACTIVATED T CELLS ST VINCENTS HOSP SYDNEY (AU) 2009-04-01 EP claimed
EP-1996936-A1 A METHOD FOR DETECTING ANTIGEN-SPECIFIC OR MITOGEN-ACTIVATED T CELLS ST VINCENT'S HOSPITAL SYDNEY LIMITED (AU) 2008-12-03 EP claimed
WO-2007106939-A1 A METHOD FOR DETECTING ANTIGEN-SPECIFIC OR MITOGEN-ACTIVATED T CELLS ST VINCENT'S HOSPITAL SYDNEY LIMITED (AU) 2007-09-27 WO claimed
US-20050271685-A1 Cellular permissivity factor for viruses and uses thereof PHARMACIA AND UPJOHN COMPANY, LLC (US) 2005-12-08 US claimed
US-6355280-B1 FOR INHIBITING CELLULAR AGING AND FOR PROTECTION OF THE SKIN AGAINST NEGATIVE ENVIRONMENTAL FACTORS AND POLLUTANTS I.M.S. COSMETICS (IL) 2002-03-12 US claimed
US-20240108673-A1 BOTANICAL FORMULATIONS MARY KAY INC. 2024-04-04 US disclosed
US-11912664-B2 Determining small molecule-protein and protein-protein interactions PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2024-02-27 US disclosed
US-20240050505-A1 BOTANICAL FORMULATIONS MARY KAY INC. 2024-02-15 US disclosed
WO-2023229891-A1 NOVEL IMMUNODULATING SMALL MOLECULES AYUVIS RESEARCH, INC. (US) 2023-11-30 WO disclosed
US-11723954-B2 Therapeutic and cosmetic uses and applications of calreticulin NEW YORK UNIVERSITY (US) 2023-08-15 US disclosed
WO-2023086877-A1 NOVEL COMPOSITIONS AND THERAPEUTIC METHODS AYUVIS RESEARCH, INC. (US) 2023-05-19 WO disclosed
US-11638735-B2 Botanical formulations MARY KAY INC. (US) 2023-05-02 US disclosed
US-4965195-A CELL CULTURE; REACTION PRODUCT OF DNA STRAND AND OLIGONUCLEOTIDE IMMUNEX CORP. (US) 1990-10-23 US disclosed
WO-1989008114-A1 RAPID IMMUNOSELECTION CLONING METHOD THE GENERAL HOSPITAL CORPORATION (US) 1989-09-08 WO disclosed
EP-0330191-A2 DNA encoding CD40 THE GENERAL HOSPITAL CORPORATION (US) 1989-08-30 EP disclosed
WO-1989003884-A1 INTERLEUKIN-7 IMMUNEX CORPORATION (US) 1989-05-05 WO disclosed
EP-0314415-A2 Interleukin-7 IMMUNEX CORPORATION (US) 1989-05-03 EP disclosed
WO-1988007854-A1 NEW ANTI-RETROVIRAL AGENTS AND DELIVERY SYSTEM UNITED STATES OF AMERICA, REPRESENTED BY THE UNITE (US) 1988-10-20 WO disclosed
EP-0286418-A1 Anti-retroviral agents and delivery systems for the same THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) 1988-10-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11912664-B2 Determining small molecule-protein and protein-protein interactions MAX, IK, CRYAA PRKCA 592/4885PRKCG 566/4885PRKD3 244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.