Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | FAAH | O00519 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365727 | 0.88 | ADORA2B (0.55) | DRD3LMNADRD2ALDH1A1HTR7 | |
| SCHEMBL10365793 | 0.85 | DRD2 (0.61) | DRD3DRD2ALDH1A1KMT2A | |
| SCHEMBL10366024 | 0.83 | SIGMAR1 (0.56) | DRD3DRD2ALDH1A1KMT2AHTR7 | |
| SCHEMBL10365769 | 0.82 | DRD2 (0.61) | DRD3DRD2 | |
| SCHEMBL22882677 | 0.79 | MGAM (0.43) | DRD3DRD2ALDH1A1TSHRKMT2A | |
| SCHEMBL314201 | 0.79 | ALDH1A1 (0.56) | DRD3ADRA1AADRA1DADRA1BMAPT | |
| SCHEMBL10364966 | 0.78 | HTR1A (0.63) | DRD3DRD2HTR7 | |
| SCHEMBL10365050 | 0.78 | MAOB (0.56) | LMNAMAPTALDH1A1KMT2AHTR7 | |
| SCHEMBL11634761 | 0.78 | TMEM97 (0.55) | DRD3ADRA1AFAAHADRA1DADRA1B | |
| SCHEMBL10367299 | 0.77 | ADRA1B (0.52) | ADRA1AADRA1DADRA1BLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0094159-B1 | DIHYDROPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-03-14 | — | — | EP | disclosed |
| US-4892875-A | HYPOTENSIVE, RENAL VASODILATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| EP-0138505-A2 | Dihydropyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-04-24 | — | — | EP | disclosed |
| EP-0094159-A1 | Dihydropyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-11-16 | — | — | EP | disclosed |