Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LAP3 | P28838 | 3/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.40 |
| ▸ | GRN | P28799 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290743 | 1.00 | OPRD1 (0.46) | OPRD1ALDH1A1OPRM1OPRK1MAPT | |
| SCHEMBL6367826 | 0.93 | OPRM1 (0.44) | OPRD1ALDH1A1OPRM1OPRK1MAPT | |
| SCHEMBL6367814 | 0.93 | OPRM1 (0.44) | OPRD1ALDH1A1OPRM1OPRK1MAPT | |
| SCHEMBL11127918 | 0.91 | ALDH1A1 (0.49) | OPRD1ALDH1A1OPRM1OPRK1MAPT | |
| SCHEMBL29692448 | 0.89 | REN (0.39) | OPRD1ALDH1A1OPRM1OPRK1MAPT | |
| SCHEMBL30964329 | 0.89 | OPRD1 (0.44) | OPRD1ALDH1A1OPRM1OPRK1MAPT | |
| SCHEMBL30808873 | 0.89 | ALDH1A1 (0.46) | OPRD1ALDH1A1OPRM1OPRK1MAPT | |
| SCHEMBL3873046 | 0.87 | ALDH1A1 (0.45) | OPRD1ALDH1A1OPRM1OPRK1MAPT | |
| SCHEMBL10773882 | 0.87 | MME (0.43) | OPRD1OPRM1OPRK1MME | |
| SCHEMBL30946331 | 0.87 | MME (0.43) | OPRD1OPRM1OPRK1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0316769-A2 | Disulfide bridged cyclic peptides containing a cgridri sequence useful in control of hypertension | G.D. Searle & Co. (US) | 1989-05-24 | — | — | EP | claimed |
| EP-0316769-A3 | DISULFIDE BRIDGED CYCLIC PEPTIDES CONTAINING A CGRIDRI SEQUENCE USEFUL IN CONTROL OF HYPERTENSION | G.D. Searle & Co. (US) | 1990-07-18 | — | — | EP | disclosed |
| EP-0316769-A2 | Disulfide bridged cyclic peptides containing a cgridri sequence useful in control of hypertension | G.D. Searle & Co. (US) | 1989-05-24 | — | — | EP | disclosed |
| EP-0316769-A2 | Disulfide bridged cyclic peptides containing a cgridri sequence useful in control of hypertension | G.D. Searle & Co. (US) | 1989-05-24 | — | — | EP | disclosed |