SCHEMBL729496

SCHEMBL729496

CCC(C)(C)[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12193776 0.78 TSHR (0.30) TSHRTDP1
SCHEMBL302654 0.74 TSHR (0.36) TSHRTDP1
SCHEMBL301818 0.72 TSHR (0.30) TSHRTDP1
SCHEMBL729499 0.72
SCHEMBL15086576 0.71 TSHR (0.33) TSHRTDP1
SCHEMBL14557372 0.65
SCHEMBL19176804 0.65 ALDH1A1 (0.40) TSHRTDP1
SCHEMBL13791520 0.65
SCHEMBL13243456 0.63
SCHEMBL15898452 0.63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103642241-A Silicone composition MOMENTIVE PERFORMANCE MAT INC 2014-03-19 CN claimed
JP-2011527341-A 2011-10-27 JP claimed
US-8017687-B2 Swollen silicone composition and process of producing same MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2011-09-13 US claimed
EP-2296667-A2 SILICONE COMPOSITION Momentive Performance Materials Inc. (US) 2011-03-23 EP claimed
EP-2228053-A1 Swollen silicone composition and process of producing same Momentive Performance Materials Inc. (US) 2010-09-15 EP claimed
JP-2010515566-A 2010-05-13 JP claimed
WO-2010005538-A2 SILICONE COMPOSITION MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2010-01-14 WO claimed
US-20100003201-A1 Silicone composition MOMENTIVE PERFORMANCE MATERIALS, INC. 2010-01-07 US claimed
EP-2108028-A2 METHOD OF APPLYING A COMPOSITION Momentive Performance Materials Inc. (US) 2009-10-14 EP claimed
EP-1968533-A1 SWOLLEN SILICONE COMPOSITION AND PROCESS OF PRODUCING SAME Momentive Performance Materials Inc. (US) 2008-09-17 EP claimed
WO-2008088323-A2 METHOD OF APPLYING A COMPOSITION MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2008-07-24 WO claimed
US-20070160547-A1 Method of applying a composition MOMENTIVE PERFORMANCE MATERIALS INC. 2007-07-12 US claimed
WO-2007058825-A1 SWOLLEN SILICONE COMPOSITION AND PROCESS OF PRODUCING SAME MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2007-05-24 WO claimed
US-20070112146-A1 Swollen silicone composition, process of producing same and products thereof MOMENTIVE PERFORMANCE MATERIALS INC. 2007-05-17 US claimed
US-20070112112-A1 Swollen silicone composition and process of producing same MOMENTIVE PERFORMANCE MATERIALS INC. 2007-05-17 US claimed
US-20040197284-A1 Cosmetic composition comprising a volatile fatty phase L'OREAL S.A. (FR) 2004-10-07 US claimed
EP-3768762-B1 SILICONE POLYMER MOMENTIVE PERFORMANCE MAT INC (US) 2025-02-19 EP disclosed
EP-3558222-B1 WATER-IN-OIL EMULSION COMPRISING A PARTICULAR EMULSIFYING SYSTEM, A LIPOPHILIC CLAY, AND AN ORGANOPOLYSILOXANE ELASTOMER POWDER COATED WITH A SILICONE RESIN OREAL (FR) 2024-04-03 EP disclosed
WO-2006013413-A1 COSMETIC COMPOSITION COMPRISING A VOLATILE LINEAR ALKYLTRISILOXANE L'OREAL (FR) 2006-02-09 WO disclosed
US-20040197284-A1 Cosmetic composition comprising a volatile fatty phase L'OREAL S.A. (FR) 2004-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100003201-A1 Silicone composition CUTA, SMURF1, MMS19 TSHR 3819/4885TDP1 1473/4885
US-20070112146-A1 Swollen silicone composition, process of producing same and products thereof PIEZO1, SMS, ALG3 TSHR 4427/4885TDP1 2055/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.