Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 10/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.53 |
| ▸ | ITGAV | P06756 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295680 | 1.00 | MEN1 (0.56) | MEN1KMT2AITGB3ITGA2BITGAV | |
| SCHEMBL3643477 | 0.90 | ITGB3 (0.58) | MEN1KMT2AITGB3ITGA2BITGAV | |
| SCHEMBL3643481 | 0.90 | ITGB3 (0.58) | MEN1KMT2AITGB3ITGA2BITGAV | |
| SCHEMBL18244718 | 0.88 | MEN1 (0.53) | MEN1KMT2AITGB3ITGA2BITGAV | |
| SCHEMBL19509029 | 0.86 | ITGB3 (0.60) | MEN1KMT2AITGB3ITGA2BITGAV | |
| SCHEMBL9825306 | 0.82 | ITGA4 (0.57) | MEN1KMT2AITGB3ITGA2BITGAV | |
| SCHEMBL28436612 | 0.82 | ITGB3 (0.49) | MEN1KMT2AITGB3ITGA2BITGAV | |
| SCHEMBL28441360 | 0.82 | ITGB3 (0.49) | MEN1KMT2AITGB3ITGA2BITGAV | |
| SCHEMBL7322052 | 0.82 | ITGA4 (0.62) | ITGB3ITGA2BITGAVITGA4ITGB7 | |
| SCHEMBL14562452 | 0.81 | ITGA4 (0.56) | MEN1KMT2AITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643072-B1 | 2-Piperazinone compounds and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-02-24 | — | — | EP | disclosed |
| EP-0643072-A1 | 2-Piperazinone compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1995-03-15 | — | — | EP | disclosed |