Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 1/20 | 0.57 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.53 |
| ▸ | ITGAV | P06756 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.53 |
| ▸ | FPR2 | P25090 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 3/20 | 0.52 |
| ▸ | CTSB | P07858 | 3/20 | 0.52 |
| ▸ | CTSS | P25774 | 3/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685892 | 0.90 | ITGB3 (0.56) | MEN1KMT2ATYRITGB3ITGAV | |
| SCHEMBL29838907 | 0.90 | ITGB3 (0.56) | MEN1KMT2ATYRITGB3ITGAV | |
| SCHEMBL9995879 | 0.88 | ITGA4 (0.54) | ITGA4ITGB7MEN1KMT2ATYR | |
| SCHEMBL29107666 | 0.88 | ITGA4 (0.56) | ITGA4ITGB7MEN1KMT2AITGB3 | |
| SCHEMBL9744805 | 0.87 | TYR (0.58) | TYRITGB3ITGAVALDH1A1ALOX15 | |
| SCHEMBL30319896 | 0.87 | TYR (0.58) | TYRITGB3ITGAVALDH1A1ALOX15 | |
| SCHEMBL9744810 | 0.87 | TYR (0.58) | TYRITGB3ITGAVALDH1A1ALOX15 | |
| SCHEMBL28806163 | 0.86 | ITGB3 (0.53) | TYRITGB3ITGA2BCTSLCTSB | |
| SCHEMBL28806164 | 0.86 | ITGB3 (0.53) | TYRITGB3ITGA2BCTSLCTSB | |
| SCHEMBL14562452 | 0.85 | ITGA4 (0.56) | ITGA4ITGB7MEN1KMT2AITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |