Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287369 | 0.88 | TP53 (0.51) | ROCK2ROCK1LMNAKMT2ASMYD3 | |
| SCHEMBL7294948 | 0.88 | PRKAB2 (0.56) | LTA4HACKR3 | |
| SCHEMBL7296573 | 0.84 | SMYD3 (0.46) | ROCK2ROCK1LMNAKMT2ASMYD3 | |
| SCHEMBL7374128 | 0.83 | LMNA (0.58) | ROCK2ROCK1LMNAKMT2ALTA4H | |
| SCHEMBL7294386 | 0.82 | SMYD3 (0.55) | LMNAKMT2ASMYD3ALDH1A1GAA | |
| SCHEMBL7297231 | 0.79 | SMYD3 (0.61) | LMNAKMT2ASMYD3ALDH1A1GAA | |
| SCHEMBL2571386 | 0.75 | ROCK2 (1.00) | ROCK2ROCK1CCR3 | |
| SCHEMBL11040553 | 0.75 | MEN1 (0.62) | LMNAKMT2AALDH1A1 | |
| SCHEMBL8094101 | 0.74 | POLB (0.65) | ROCK2ROCK1KMT2AACKR3CCR3 | |
| Hydrochloric Acid SCHEMBL7292922 | 0.74 | CHRM2 (0.59) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5306719-A | Cardiotonic agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-26 | — | — | US | disclosed |
| EP-0255134-B1 | CARBOSTYRIL DERIVATIVES AND SALTS THEREOF, PROCESS FOR PREPARING THEM, AND CARDIOTONIC COMPOSITION CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-5071856-A | CARBOSTYRIL DERIVATIVES AND SALTS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-10 | — | — | US | disclosed |
| US-4886809-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-12-12 | — | — | US | disclosed |
| EP-0255134-A2 | Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-03 | — | — | EP | disclosed |