Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295865 | 0.88 | ROCK2 (0.60) | GAAALDH1A1LMNASMYD3ROCK2 | |
| SCHEMBL7294948 | 0.82 | PRKAB2 (0.56) | TP53 | |
| SCHEMBL7294386 | 0.79 | SMYD3 (0.55) | TP53GAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7296573 | 0.79 | SMYD3 (0.46) | TP53GAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7297231 | 0.78 | SMYD3 (0.61) | TP53GAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7374128 | 0.72 | LMNA (0.58) | GAALMNAROCK2ROCK1KMT2A | |
| SCHEMBL23143564 | 0.69 | SMYD3 (0.68) | TP53GAALMNASMYD3ROCK2 | |
| SCHEMBL16413790 | 0.69 | HDAC3 (0.47) | TP53GAALMNASMN1; SMN2SMYD3 | |
| SCHEMBL20291405 | 0.68 | PKM (0.58) | LMNATRPV1MEN1KMT2AHDAC3 | |
| SCHEMBL10366740 | 0.68 | HDAC3 (0.61) | SMYD3HDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255134-A2 | Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-03 | — | — | EP | disclosed |