Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | FOS | P01100 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302581 | 0.91 | ALDH1A1 (0.43) | LCKMAPTALDH1A1EGFRTP53 | |
| SCHEMBL11854802 | 0.87 | LCK (0.55) | LCKMAPTALDH1A1EGFRTP53 | |
| SCHEMBL7298898 | 0.85 | MAPT (0.42) | LCKMAPTALDH1A1EGFRTP53 | |
| SCHEMBL10955169 | 0.81 | LNPEP (0.51) | ALDH1A1TP53ACACBNPSR1BACE1 | |
| SCHEMBL7304249 | 0.80 | ALOX15 (0.46) | LCKALDH1A1EGFRFOSTTR | |
| SCHEMBL1069133 | 0.80 | ALOX15 (0.44) | MAPTALDH1A1TP53ACACBTACR1 | |
| SCHEMBL7302573 | 0.79 | MAPT (0.42) | LCKMAPTALDH1A1EGFRTP53 | |
| SCHEMBL11022951 | 0.77 | TP53 (0.59) | ALDH1A1EGFRTP53LMNATACR1 | |
| SCHEMBL11155440 | 0.77 | TP53 (0.59) | ALDH1A1EGFRTP53LMNATACR1 | |
| SCHEMBL7294526 | 0.77 | LCK (0.41) | LCKMAPTALDH1A1EGFRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393781-B1 | Dopamine pro-drug | ZAMBON SPA (IT) | 1995-02-08 | — | — | EP | disclosed |
| US-5073547-A | DOPAMINE PRO-DRUG | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-17 | — | — | US | disclosed |
| EP-0393781-A2 | Dopamine pro-drug | ZAMBON GROUP S.p.A. (IT) | 1990-10-24 | — | — | EP | disclosed |