Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 16/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303661 | 0.94 | CTSS (0.45) | CTSSADRB1ADRB2ADRB3KDM4E | |
| SCHEMBL9687213 | 0.88 | MAPK1 (0.44) | ADRB1ADRB2ADRB3MEN1CYP1A2 | |
| SCHEMBL7306568 | 0.87 | ADRB2 (0.39) | ADRB1ADRB2ADRB3KDM4ECYP1A2 | |
| SCHEMBL7303996 | 0.86 | CTSS (0.43) | CTSSADRB1ADRB2ADRB3KDM4E | |
| SCHEMBL7302924 | 0.82 | MEN1 (0.39) | ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL9688183 | 0.82 | CTSS (0.48) | CTSSADRB1ADRB2ADRB3KDM4E | |
| SCHEMBL7306574 | 0.81 | ADRB2 (0.39) | ADRB1ADRB2ADRB3KDM4ECYP1A2 | |
| SCHEMBL7304010 | 0.80 | PDE3B (0.43) | CTSSADRB1ADRB2ADRB3KDM4E | |
| SCHEMBL7302583 | 0.78 | MAPT (0.42) | ADRB1ADRB2ADRB3KMT2A | |
| SCHEMBL9687567 | 0.77 | KMT2A (0.39) | ADRB3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |