Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | ECE1 | P42892 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7303875 | 0.83 | MAPT (0.41) | MEN1KMT2AMMEECE1 | |
| SCHEMBL7299013 | 0.81 | DYRK1A (0.37) | HTTGPR119MEN1KMT2AEGFR | |
| SCHEMBL7295525 | 0.78 | PDE3B (0.40) | GPR119 | |
| SCHEMBL9687230 | 0.77 | MAPK1 (0.45) | HTTCYP2C9 | |
| SCHEMBL7304445 | 0.74 | PDE3B (0.39) | GPR119 | |
| SCHEMBL7303724 | 0.71 | RAD52 (0.43) | GPR119MEN1KMT2ACYP2C9PDE10A | |
| SCHEMBL9688183 | 0.68 | CTSS (0.48) | MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL7331760 | 0.64 | SMN1; SMN2 (0.40) | GPR119KMT2AMMEECE1 | |
| SCHEMBL7303740 | 0.63 | RAD52 (0.52) | GPR119MEN1KMT2AKDM4E | |
| SCHEMBL8043227 | 0.61 | EGFR (0.55) | HTTMEN1KMT2AEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |