Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 13/20 | 0.77 |
| ▸ | HTR1A | P08908 | 10/20 | 0.74 |
| ▸ | DRD2 | P14416 | 2/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | PARP1 | P09874 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301822 | 0.90 | HTR1A (0.63) | HTR7HTR1ADRD2HTR2AADRA2A | |
| SCHEMBL7309594 | 0.89 | HTR7 (0.68) | HTR7HTR1ADRD2ADRA2AADRA2B | |
| SCHEMBL7300725 | 0.88 | HTR7 (0.67) | HTR7HTR1ADRD2ADRA2AADRA2B | |
| SCHEMBL7305169 | 0.88 | HTR1A (0.61) | HTR7HTR1ADRD2HTR2AADRA2A | |
| SCHEMBL8131304 | 0.87 | HTR7 (1.00) | HTR7HTR1ADRD2ADRA2AADRA2B | |
| SCHEMBL7297796 | 0.86 | HTR1A (0.68) | HTR7HTR1ADRD2HTR2A | |
| SCHEMBL18010368 | 0.85 | HTR7 (0.70) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL8128438 | 0.85 | HTR7 (1.00) | HTR7HTR1ADRD2ADRA2AADRA2B | |
| SCHEMBL7306583 | 0.85 | HTR1A (0.70) | HTR7HTR1ADRD2HTR2A | |
| SCHEMBL18028066 | 0.84 | HTR7 (0.71) | HTR7HTR1ADRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |