Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.63 |
| ▸ | DRD2 | P14416 | 5/20 | 0.63 |
| ▸ | HTR2A | P28223 | 4/20 | 0.63 |
| ▸ | HTR7 | P34969 | 9/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.54 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305169 | 0.92 | HTR1A (0.61) | HTR1ADRD2HTR2AHTR7ADRA1B | |
| SCHEMBL7300518 | 0.90 | HTR7 (0.77) | HTR1ADRD2HTR2AHTR7ADRB2 | |
| SCHEMBL7301705 | 0.86 | LMNA (0.61) | HTR1ADRD2HTR2AHTR7ADRA1B | |
| SCHEMBL7297796 | 0.84 | HTR1A (0.68) | HTR1ADRD2HTR2AHTR7ADRA1B | |
| SCHEMBL7306583 | 0.83 | HTR1A (0.70) | HTR1ADRD2HTR2AHTR7ADRA1B | |
| SCHEMBL7299129 | 0.82 | HTR1A (0.68) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7309594 | 0.80 | HTR7 (0.68) | HTR1ADRD2HTR7ADRA1BADRA1D | |
| SCHEMBL2351486 | 0.80 | ADRA1B (0.75) | HTR1ADRD2HTR2AHTR7ADRA1B | |
| SCHEMBL7297432 | 0.80 | HTR7 (0.74) | HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7300725 | 0.79 | HTR7 (0.67) | HTR1ADRD2HTR7ADRA1BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |