Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.70 |
| ▸ | DRD2 | P14416 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | HTR7 | P34969 | 10/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312723 | 0.89 | HTR1A (0.57) | HTR1ADRD2HTR2AHTR7ADRA1B | |
| SCHEMBL7297796 | 0.88 | HTR1A (0.68) | HTR1ADRD2HTR2AHTR7ADRA1B | |
| SCHEMBL7299129 | 0.88 | HTR1A (0.68) | HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL8136027 | 0.86 | HTR7 (0.72) | HTR1AHTR7LMNA | |
| SCHEMBL7298673 | 0.85 | HTR1A (0.56) | HTR1ADRD2HTR2AHTR7ADRA1B | |
| SCHEMBL7300518 | 0.85 | HTR7 (0.77) | HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7297432 | 0.85 | HTR7 (0.74) | HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7303729 | 0.84 | HTR1A (0.64) | HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7301822 | 0.83 | HTR1A (0.63) | HTR1ADRD2HTR2AHTR7ADRA1B | |
| SCHEMBL7305169 | 0.81 | HTR1A (0.61) | HTR1ADRD2HTR2AHTR7ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763523-B1 | QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2013-03-20 | — | — | EP | claimed |
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |