Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 11/20 | 0.67 |
| ▸ | HTR1A | P08908 | 8/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133693 | 0.90 | HTR7 (0.80) | HTR7HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL7300518 | 0.88 | HTR7 (0.77) | HTR7HTR1AADRA2AADRA2BADRB2 | |
| SCHEMBL7312723 | 0.88 | HTR1A (0.57) | HTR7HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL7309594 | 0.84 | HTR7 (0.68) | HTR7HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8136613 | 0.82 | HTR7 (0.76) | HTR7HTR1AADRA2AADRA2BADRB2 | |
| SCHEMBL8131304 | 0.80 | HTR7 (1.00) | HTR7HTR1AADRA2AADRA2BADRB2 | |
| SCHEMBL10809128 | 0.79 | ADRA2A (0.78) | HTR7HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8125943 | 0.79 | HTR7 (0.81) | HTR7HTR1AADRA2AADRA2BADRB2 | |
| SCHEMBL8943310 | 0.79 | HTR7 (0.81) | HTR7HTR1AADRA2AADRA2BADRB2 | |
| SCHEMBL7301822 | 0.79 | HTR1A (0.63) | HTR7HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |