Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.56 |
| ▸ | MMP3 | P08254 | 8/20 | 0.56 |
| ▸ | MMP2 | P08253 | 8/20 | 0.56 |
| ▸ | MMP13 | P45452 | 10/20 | 0.55 |
| ▸ | MMP9 | P14780 | 8/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309436 | 0.88 | MMP1 (0.50) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7298812 | 0.77 | MMP1 (0.42) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7307517 | 0.77 | ADAM17 (0.43) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7309053 | 0.76 | MMP3 (0.78) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL14188829 | 0.73 | MMP1 (0.56) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7306444 | 0.73 | MMP1 (0.65) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL6928607 | 0.72 | MMP1 (1.00) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL6934594 | 0.71 | MMP1 (0.73) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL6931861 | 0.70 | MMP1 (0.52) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL8714771 | 0.69 | MMP13 (0.73) | MMP1MMP3MMP2MMP13MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |