Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.50 |
| ▸ | MMP3 | P08254 | 8/20 | 0.50 |
| ▸ | MMP2 | P08253 | 7/20 | 0.50 |
| ▸ | MMP13 | P45452 | 7/20 | 0.45 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302606 | 0.88 | MMP1 (0.56) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7308312 | 0.79 | ALDH1A1 (0.41) | MMP1MMP3MMP13MMP9ADAM17 | |
| SCHEMBL7311450 | 0.78 | MMP3 (0.63) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7301899 | 0.75 | MMP1 (0.49) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7305749 | 0.74 | MMP13 (0.71) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7309053 | 0.69 | MMP3 (0.78) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL6931861 | 0.68 | MMP1 (0.52) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7310255 | 0.67 | EPHX2 (0.43) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL27461841 | 0.66 | ALDH1A1 (0.42) | MMP1MMP3MMP2MMP13MMP9 | |
| SCHEMBL7298812 | 0.66 | MMP1 (0.42) | MMP1MMP3MMP2MMP13MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |