SCHEMBL7302796

SCHEMBL7302796

C1=CC2=CC=C1C2.O=C(CCS(=O)(=O)c1ccc(-c2ccccc2)cc1)NO

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 10/20 0.59
MMP2 P08253 5/20 0.58
MMP9 P14780 4/20 0.58
MMP14 P50281 4/20 0.58
MMP7 P09237 3/20 0.58
MMP3 P08254 3/20 0.58
MMP13 P45452 3/20 0.58
HDAC2 Q92769 4/20 0.52
HDAC1 Q13547 3/20 0.52
HDAC3 O15379 1/20 0.52
HDAC4 P56524 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
HDAC6 Q9UBN7 1/20 0.52
HDAC9 Q9UKV0 1/20 0.52
HDAC5 Q9UQL6 1/20 0.52
MMP8 P22894 2/20 0.49
MMP12 P39900 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7307785 0.87 MMP2 (0.54) MMP1MMP2MMP9MMP14MMP7
SCHEMBL6580386 0.80 HDAC3 (0.76) MMP1MMP2MMP9MMP14MMP7
SCHEMBL7297071 0.74 HSD11B1 (0.51) L3MBTL1POLBCTDSP1
SCHEMBL7010023 0.74 MMP2 (0.68) MMP1MMP2MMP9MMP14MMP7
SCHEMBL27466099 0.71 MMP2 (0.59) MMP1MMP2MMP9MMP14MMP7
SCHEMBL7862104 0.71 HDAC1 (0.57) MMP1MMP2MMP9MMP14MMP7
SCHEMBL7324083 0.69 HDAC1 (1.00) MMP1HDAC2HDAC1HDAC3HDAC4
SCHEMBL5602773 0.68 MMP1 (1.00) MMP1L3MBTL1POLBCTDSP1
SCHEMBL6388043 0.68 HDAC2 (0.65) MMP1MMP2MMP9MMP14MMP7
SCHEMBL6823331 0.68 MMP1 (0.63) MMP1HDAC2HDAC1HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0780386-B1 Matrix metalloprotease inhibitors HOFFMANN LA ROCHE (CH) 2002-10-02 EP disclosed
US-5932595-A ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT SYNTEX (U.S.A.) INC. (US) 1999-08-03 US disclosed
EP-0780386-A1 Matrix metalloprotease inhibitors F. HOFFMANN-LA ROCHE AG (CH) 1997-06-25 EP disclosed