Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | MMP7 | P09237 | 2/20 | 0.54 |
| ▸ | MMP14 | P50281 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010023 | 0.88 | MMP2 (0.68) | MMP2MMP7MMP14HTTNPSR1 | |
| SCHEMBL7302796 | 0.87 | MMP1 (0.59) | MMP2MMP7MMP14HDAC1HDAC2 | |
| SCHEMBL7297071 | 0.84 | HSD11B1 (0.51) | HTTNPSR1KDM4EALDH1A1HSD11B1 | |
| SCHEMBL1001018 | 0.78 | HSD11B1 (0.69) | HTTNPSR1KDM4EHDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL10584023 | 0.76 | HSD11B1 (0.67) | HTTNPSR1KDM4EHDAC1HDAC2 | |
| SCHEMBL7010857 | 0.75 | HSD11B1 (0.58) | MMP2MMP7MMP14HTTNPSR1 | |
| SCHEMBL27466099 | 0.75 | MMP2 (0.59) | MMP2MMP7MMP14HDAC1HDAC2 | |
| SCHEMBL7014945 | 0.74 | HTT (0.55) | MMP2MMP7MMP14HTTNPSR1 | |
| SCHEMBL7077673 | 0.72 | HTT (0.50) | MMP2MMP7MMP14HTTNPSR1 | |
| SCHEMBL7075505 | 0.72 | HSD11B1 (0.62) | MMP2MMP7MMP14HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |