Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687567 | 0.94 | KMT2A (0.39) | MEN1KMT2AOPRL1PDE4APDE4B | |
| SCHEMBL9687213 | 0.84 | MAPK1 (0.44) | MEN1KMT2AADRB1SMN1; SMN2NPSR1 | |
| SCHEMBL7303647 | 0.82 | CTSS (0.45) | MEN1KMT2AADRB1ADRB3 | |
| SCHEMBL7306568 | 0.82 | ADRB2 (0.39) | KMT2AADRB1PDE4APDE4BPDE4C | |
| SCHEMBL7302583 | 0.79 | MAPT (0.42) | KMT2AADRB1ADRB3 | |
| SCHEMBL7306574 | 0.77 | ADRB2 (0.39) | KMT2AADRB1PDE4APDE4BPDE4C | |
| SCHEMBL7303661 | 0.77 | CTSS (0.45) | MEN1KMT2AADRB1ADRB3 | |
| SCHEMBL9463196 | 0.75 | SLC2A1 (0.41) | MEN1KMT2AOPRL1ADRB1PDE4A | |
| SCHEMBL9463189 | 0.75 | SLC2A1 (0.41) | MEN1KMT2AOPRL1ADRB1PDE4A | |
| SCHEMBL7302590 | 0.73 | MAPT (0.42) | KMT2AADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |