Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306568 | 0.94 | ADRB2 (0.39) | ADRB2ADRB1HTR1ASLC22A1HTR2A | |
| SCHEMBL7303661 | 0.87 | CTSS (0.45) | ADRB2ADRB1CYP1A2ADRB3KDM4E | |
| SCHEMBL7305060 | 0.86 | PDE3B (0.43) | ADRB2ADRB1HTR1ASLC22A1HTR2A | |
| SCHEMBL9687567 | 0.82 | KMT2A (0.39) | ADRB3KMT2APDE4APDE4BPDE4C | |
| SCHEMBL9687213 | 0.82 | MAPK1 (0.44) | ADRB2ADRB1HTR1ASLC22A1HTR2A | |
| SCHEMBL7303647 | 0.81 | CTSS (0.45) | ADRB2ADRB1CYP1A2ADRB3KDM4E | |
| SCHEMBL7305054 | 0.80 | SLC22A1 (0.39) | ADRB2ADRB1HTR1ASLC22A1HTR2A | |
| SCHEMBL7302590 | 0.79 | MAPT (0.42) | ADRB2ADRB1LMNAADRB3MAPT | |
| SCHEMBL7304441 | 0.78 | ADRB2 (0.43) | ADRB2ADRB1HTR1ASLC6A4ADRA1A | |
| SCHEMBL7302924 | 0.77 | MEN1 (0.39) | ADRB1ADRB3KMT2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |