Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301647 | 0.85 | ALDH1A1 (0.51) | POLBKMT2AHPGDPTPN1L3MBTL1 | |
| SCHEMBL7435315 | 0.81 | CTSL (0.50) | POLBPSMB5 | |
| SCHEMBL7435291 | 0.81 | CTSL (0.50) | POLBPSMB5 | |
| SCHEMBL7435297 | 0.81 | KMT2A (0.49) | POLBKMT2AHPGDPTPN1L3MBTL1 | |
| SCHEMBL7303805 | 0.77 | ALDH1A1 (0.52) | POLBKMT2AHPGDPTPN1L3MBTL1 | |
| SCHEMBL7311218 | 0.76 | ALDH1A1 (0.52) | POLBKMT2AHPGDL3MBTL1MEN1 | |
| SCHEMBL7302483 | 0.74 | ALDH1A1 (0.51) | POLBKMT2AHPGDL3MBTL1MEN1 | |
| SCHEMBL7307788 | 0.72 | L3MBTL1 (0.48) | POLBHPGDL3MBTL1ADAMTS5 | |
| SCHEMBL12226097 | 0.72 | GPR34 (0.56) | KMT2AHPGDMEN1PSMB5 | |
| SCHEMBL7435308 | 0.70 | SMN1; SMN2 (0.41) | POLBKMT2APTPN1HDAC8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |