Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 5/20 | 0.48 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 4/20 | 0.46 |
| ▸ | CASP7 | P55210 | 4/20 | 0.46 |
| ▸ | CASP6 | P55212 | 4/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | CPA2 | P48052 | 1/20 | 0.44 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435315 | 1.00 | CTSL (0.50) | CTSLCTSBCASP3RENCASP1 | |
| SCHEMBL7301641 | 0.84 | ALDH1A1 (0.48) | CTSLCTSBCASP3RENCASP1 | |
| SCHEMBL7301631 | 0.84 | ALDH1A1 (0.48) | CTSLCTSBCASP3RENCASP1 | |
| SCHEMBL7304278 | 0.82 | CTSL (0.68) | CTSLCTSB | |
| SCHEMBL7304260 | 0.82 | CTSL (0.68) | CTSLCTSB | |
| SCHEMBL7302949 | 0.81 | POLB (0.43) | POLBPSMB5 | |
| SCHEMBL22582338 | 0.80 | MMP2 (0.48) | CTSBCASP3CASP1CASP7CASP6 | |
| SCHEMBL7305024 | 0.79 | PSMB5 (0.53) | RENPSMB5 | |
| SCHEMBL7305034 | 0.79 | PSMB5 (0.53) | RENPSMB5 | |
| SCHEMBL8823888 | 0.78 | CASP3 (0.56) | CASP3RENCASP1CASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |