Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.39 |
| ▸ | C1S | P09871 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300903 | 0.99 | TERT (0.40) | TERTALDH1A1GAAHTTIDO1 | |
| SCHEMBL1924454 | 0.78 | ALDH1A1 (0.53) | ALDH1A1GAAHTTKCNH2SMN1; SMN2 | |
| SCHEMBL3159432 | 0.71 | SMN1; SMN2 (0.50) | ALDH1A1GAAHTTC1SNPC1 | |
| SCHEMBL7167684 | 0.70 | NOS2 (0.53) | ALDH1A1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24529 | 0.69 | TP53 (0.55) | TERTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL255378 | 0.69 | ALDH1A1 (0.52) | ALDH1A1GAAHTTC1SNPC1 | |
| SCHEMBL30167608 | 0.69 | ALDH1A1 (0.52) | ALDH1A1GAAHTTC1SNPC1 | |
| SCHEMBL22685038 | 0.69 | ALDH1A1 (0.59) | TERTALDH1A1GAAHTTNPC1 | |
| SCHEMBL1924005 | 0.68 | MAP3K7 (0.52) | ALDH1A1HTTHRH3SMN1; SMN2 | |
| SCHEMBL1397693 | 0.66 | ADRA2C (0.66) | TERTALDH1A1GAAHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520200-B1 | Imidazole compounds, their preparation and use | NEUROSEARCH AS (DK) | 1998-02-18 | — | — | EP | claimed |
| US-5210091-A | Calcium channel blockers used in treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1993-05-11 | — | — | US | claimed |
| EP-0520200-A2 | Imidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1992-12-30 | — | — | EP | claimed |
| EP-0520200-B1 | Imidazole compounds, their preparation and use | NEUROSEARCH AS (DK) | 1998-02-18 | — | — | EP | disclosed |
| US-5210091-A | Calcium channel blockers used in treatment of central nervous system disorders | NEUROSEARCH A/S (DK) | 1993-05-11 | — | — | US | disclosed |
| EP-0520200-A2 | Imidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1992-12-30 | — | — | EP | disclosed |