Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 12/20 | 0.43 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304427 | 0.95 | ADRB2 (0.43) | ADRB2HTR1ATP53MAPTALDH1A1 | |
| SCHEMBL7305060 | 0.92 | PDE3B (0.43) | ADRB2HTR1APDE3BPDE3AABCB11 | |
| SCHEMBL7305054 | 0.86 | SLC22A1 (0.39) | ADRB2HTR1APDE3BPDE3AABCB11 | |
| SCHEMBL7304010 | 0.86 | PDE3B (0.43) | ADRB2PDE3BPDE3AABCB11MAOA | |
| SCHEMBL9687171 | 0.82 | PDE3B (0.41) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9687447 | 0.82 | MAPK1 (0.41) | ADRB2HTR1APDE3BPDE3ATP53 | |
| SCHEMBL7297393 | 0.81 | PDE3B (0.47) | ADRB2PDE3BPDE3AABCB11MAOA | |
| SCHEMBL7303996 | 0.81 | CTSS (0.43) | ADRB2ADRB1ADRB3CYP1A2KDM4E | |
| SCHEMBL7304432 | 0.79 | ALDH1A1 (0.45) | ADRB2HTR1AALDH1A1ADRB1LMNA | |
| SCHEMBL7303819 | 0.78 | PDE3B (0.46) | PDE3BPDE3AABCB11MAOAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |