Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305054 | 0.94 | SLC22A1 (0.39) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7304441 | 0.92 | ADRB2 (0.43) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7304010 | 0.88 | PDE3B (0.43) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7304427 | 0.86 | ADRB2 (0.43) | GPR119LMNACYP1A2ADRB2ADRB1 | |
| SCHEMBL7306574 | 0.86 | ADRB2 (0.39) | PDE3BPDE3AABCB11GPR119SLC22A1 | |
| SCHEMBL9687171 | 0.83 | PDE3B (0.41) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9687447 | 0.83 | MAPK1 (0.41) | PDE3BPDE3AGPR119SLC22A1LMNA | |
| SCHEMBL7303996 | 0.82 | CTSS (0.43) | GPR119CYP1A2ADRB2ADRB1 | |
| SCHEMBL7305182 | 0.82 | HRH3 (0.46) | PDE3BPDE3AGPR119SLC22A1LMNA | |
| SCHEMBL7303255 | 0.81 | GPR119 (0.42) | PDE3BPDE3AABCB11GPR119SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |