Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687154 | 0.95 | GPR119 (0.35) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7304010 | 0.85 | PDE3B (0.43) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7305060 | 0.83 | PDE3B (0.43) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9687380 | 0.83 | GPR119 (0.39) | PDE3BPDE3AGPR119ADRB3PDE4A | |
| SCHEMBL9686104 | 0.83 | HRH3 (0.43) | PDE3BPDE3AADRB3PDE4APDE4B | |
| SCHEMBL7306521 | 0.83 | ADRB1 (0.46) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7304441 | 0.82 | ADRB2 (0.43) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9687447 | 0.80 | MAPK1 (0.41) | PDE3BPDE3AGPR119ADRB3 | |
| SCHEMBL7303996 | 0.79 | CTSS (0.43) | GPR119ADRB3 | |
| SCHEMBL7297393 | 0.78 | PDE3B (0.47) | PDE3BPDE3AABCB11MAOAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |