Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311381 | 0.84 | ALOX15 (0.42) | ALDH1A1KDM4EL3MBTL1LMNAALOX15 | |
| SCHEMBL11657490 | 0.79 | HSP90AA1 (0.50) | ALDH1A1KDM4EHSP90AA1RAB9ARXFP1 | |
| SCHEMBL8988234 | 0.77 | HSP90AA1 (0.46) | ALDH1A1KDM4EHSP90AA1RAB9ARXFP1 | |
| Hydrochloric Acid SCHEMBL8655604 | 0.76 | HSP90AA1 (0.45) | ALDH1A1KDM4EHSP90AA1RAB9ARXFP1 | |
| SCHEMBL7308113 | 0.73 | SIGMAR1 (0.41) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2MAPK1 | |
| SCHEMBL8706167 | 0.73 | ALDH1A1 (0.42) | ALDH1A1KDM4EHSP90AA1RAB9ARXFP1 | |
| SCHEMBL6375003 | 0.73 | GRIN2B (0.55) | ALDH1A1KDM4EHSP90AA1NPC1SMN1; SMN2 | |
| SCHEMBL11685004 | 0.72 | ALDH1A1 (0.51) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11623381 | 0.72 | RAB9A (0.50) | ALDH1A1KDM4EHSP90AA1RAB9ARXFP1 | |
| SCHEMBL11657276 | 0.70 | POLB (0.46) | KDM4EHSP90AA1SMN1; SMN2SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | claimed |
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |