Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312043 | 0.83 | L3MBTL1 (0.51) | SIGMAR1ALDH1A1SMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL11685688 | 0.83 | ALDH1A1 (0.41) | HSD17B10ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL7304554 | 0.73 | ALDH1A1 (0.42) | SIGMAR1MAPK1HSD17B10ALDH1A1KDM4E | |
| SCHEMBL7308934 | 0.73 | TDP1 (0.43) | SIGMAR1MAPK1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8701885 | 0.70 | ALDH1A1 (0.42) | SIGMAR1MAPK1HSD17B10ALDH1A1POLB | |
| SCHEMBL2400051 | 0.70 | L3MBTL1 (0.71) | MAPK1HSD17B10ALDH1A1POLBKDM4E | |
| SCHEMBL12263487 | 0.70 | MAPK1 (0.49) | SIGMAR1MAPK1HSD17B10ALDH1A1POLB | |
| SCHEMBL16982100 | 0.67 | LTA4H (0.42) | SIGMAR1MAPK1HSD17B10ALDH1A1POLB | |
| SCHEMBL3987440 | 0.67 | KDM4E (0.38) | SIGMAR1MAPK1HSD17B10ALDH1A1POLB | |
| SCHEMBL235080 | 0.66 | KDM4E (0.65) | SIGMAR1HSD17B10ALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | claimed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | claimed |
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |