SCHEMBL7304564

SCHEMBL7304564

Cc1ccc2c(c1)CC(CC(=O)O)C2

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 6/20 0.46
DGAT1 O75907 1/20 0.41
FFAR1 O14842 1/20 0.41
SRC P12931 1/20 0.39
ITGB3 P05106 4/20 0.39
ITGA2B P08514 4/20 0.39
NAMPT P43490 1/20 0.38
METAP1 P53582 1/20 0.38
ACHE P22303 1/20 0.38
AKR1B1 P15121 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25081053 0.85 AADAT (0.41) FFAR4NAMPTMETAP1ACHE
SCHEMBL14457829 0.80 FFAR1 (0.42) FFAR4DGAT1FFAR1ITGB3ITGA2B
SCHEMBL8730184 0.80 MAPT (0.50) DGAT1FFAR1ITGB3ITGA2BNAMPT
SCHEMBL7293280 0.79 TBXA2R (0.42) FFAR4DGAT1FFAR1ITGB3ITGA2B
SCHEMBL6673906 0.79 ITGB3 (0.41) DGAT1FFAR1ITGB3ITGA2B
SCHEMBL9245560 0.79 PNMT (0.44) DGAT1ITGB3ITGA2BNAMPTMETAP1
SCHEMBL22344890 0.79 SLC6A4 (0.46) FFAR4DGAT1FFAR1ITGB3ITGA2B
SCHEMBL14439411 0.79 ELANE (0.41) FFAR4DGAT1FFAR1ITGB3ITGA2B
SCHEMBL10226240 0.79 CYP19A1 (0.54) FFAR4FFAR1ITGB3ITGA2BACHE
SCHEMBL20584776 0.78 TRPM5 (0.42) METAP1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140275179-A1 GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed
EP-0372484-B1 Condensed benzene derivative ZERIA PHARM CO LTD (JP) 1994-10-26 EP disclosed
US-5028604-A Cognition Activators ZERIA PHARMACEUTICAL CO., LTD. (JP) 1991-07-02 US disclosed
EP-0372484-A2 Condensed benzene derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 1990-06-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140275179-A1 GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES GPR119, GLP1R, GCGR FFAR4 54/4885DGAT1 754/4885FFAR1 20/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.