Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 7/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 6/20 | 0.35 |
| ▸ | MMP3 | P08254 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7796017 | 0.87 | DGAT1 (0.55) | ITGB3ITGA2BDGAT1FFAR1BRD4 | |
| SCHEMBL7316308 | 0.87 | ITGB3 (0.55) | ITGB3ITGA2BDGAT1PSEN1PSEN2 | |
| SCHEMBL16627778 | 0.86 | CA1 (0.38) | ITGB3ITGA2BPSEN1PSEN2APH1B | |
| SCHEMBL22344890 | 0.79 | SLC6A4 (0.46) | ITGB3ITGA2BDGAT1PSEN1PSEN2 | |
| SCHEMBL7304564 | 0.79 | FFAR4 (0.46) | ITGB3ITGA2BDGAT1FFAR1 | |
| SCHEMBL9245560 | 0.79 | PNMT (0.44) | ITGB3ITGA2BDGAT1 | |
| SCHEMBL7293280 | 0.79 | TBXA2R (0.42) | ITGB3ITGA2BDGAT1PSEN1PSEN2 | |
| SCHEMBL6554194 | 0.79 | ITGB3 (0.57) | ITGB3ITGA2BALDH1A1HPGD | |
| SCHEMBL6554201 | 0.79 | ITGB3 (0.57) | ITGB3ITGA2BALDH1A1HPGD | |
| SCHEMBL29633587 | 0.77 | DGAT1 (0.47) | DGAT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259495-B1 | INDANE DERIVATIVES AND THEIR USE AS CELL ADHESION INHIBITORS | AVENTIS PHARMA LTD (GB) | 2004-09-22 | — | — | EP | disclosed |
| US-6762199-B2 | ABILITY TO MODULATE THE INTERACTION OF THE LIGAND VCAM-1 WITH ITS INTEGRIN RECEPTOR ALPHA 4 BETA 1; TREATMENT OF INFLAMMATION, ATHEROSCLEROSIS, AUTOIMMUNE DISEASE | AVENTIS PHARMA LIMITED (GB) | 2004-07-13 | — | — | US | disclosed |
| US-20030199564-A1 | Indane derivatives | AVENTIS PHARMA LIMITED (GB) | 2003-10-23 | — | — | US | disclosed |
| EP-1259495-A2 | INDANE DERIVATIVES AND THEIR USE AS CELL ADHESION INHIBITORS | Aventis Pharma Limited (GB) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001064659-A2 | INDANE DERIVATIVES AND THEIR USE AS CELL ADHESION INHIBITORS | AVENTIS PHARMA LIMITED (GB) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199564-A1 | Indane derivatives | ITGA1, ITGB1, VCAM1 | ITGB3 4/4885ITGA2B 12/4885DGAT1 2662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.